Duphaston (Dydrogesterone) Tablets: Uses, Dosage, Safety and Interactions

Duphaston is a prescription progestogen containing dydrogesterone, a medicine with progesterone-like activity. In countries where it is approved, it may be prescribed for selected conditions associated with progesterone deficiency, including some menstrual disorders, endometriosis, luteal-phase infertility, abnormal uterine bleeding, and specific hormone-replacement regimens. Approved uses and treatment schedules differ by country and should be confirmed in local product information.

Abnormal bleeding, pelvic pain, irregular periods, infertility, and pregnancy symptoms have many possible causes. Duphaston should only be used after a clinician establishes the diagnosis and confirms that this treatment is appropriate. It is not a contraceptive and should not be used to self-manage suspected miscarriage, pregnancy loss, or severe bleeding.

Patients with a valid prescription may buy Duphaston from an appropriately regulated pharmacy. The Duphaston price can vary by tablet quantity, pharmacy, manufacturer, and local coverage. Cost should not lead to a changed cycle-day schedule, skipped tablets, or use of an unverified source.

Indications

Duphaston may be used for conditions related to endogenous progesterone deficiency when a qualified clinician selects it. Depending on local approval, this can include dysmenorrhea, endometriosis, secondary amenorrhea, dysfunctional uterine bleeding, luteal insufficiency, or protection of the endometrium in certain estrogen-containing hormone-replacement regimens. A separate reproductive or oncology evaluation may be required before hormone treatment is begun.

Pregnancy-related use is specialist-directed. Vaginal bleeding, severe abdominal pain, shoulder pain, dizziness, fainting, fever, or passage of tissue in pregnancy requires urgent medical assessment, including evaluation for ectopic pregnancy or other complications. Do not assume that taking a progestogen makes emergency assessment unnecessary.

Dosage

Take Duphaston exactly as prescribed. The days of the menstrual cycle, daily dose, frequency, and length of therapy depend on the condition being treated and the individual response. The medication should be spread through the day when multiple doses are prescribed. Do not follow a schedule intended for another diagnosis, and do not begin it based solely on a calendar calculation without clinician guidance.

Duphaston tablets contain 10 mg dydrogesterone. Patients with a valid prescription may buy Duphaston 10 mg when that exact strength has been prescribed. Patients with a valid prescription may buy Duphaston 10 mg only for the cycle-day regimen specified by the clinician. The Duphaston price does not determine the appropriate dose, duration, or need for pregnancy testing.

If a dose is missed, contact the prescriber or pharmacist for product- and indication-specific advice. Do not double the next dose unless explicitly instructed. Store tablets in the original container, protected from moisture and out of reach of children and pets.

Safety Information

Do not take Duphaston if you have had a serious hypersensitivity reaction to dydrogesterone or a listed ingredient. Contraindications can include certain serious liver conditions such as Dubin-Johnson or Rotor syndrome, depending on local product information. Before treatment, tell the clinician about liver disease, unexplained vaginal bleeding, depression, migraine, seizure disorders, hormone-sensitive cancer, pregnancy, breastfeeding, and all medicines.

Possible adverse effects include headache, migraine, nausea, dizziness, breast tenderness, abdominal discomfort, bloating, skin rash, itching, and spotting or breakthrough bleeding. Seek urgent care for facial or throat swelling, breathing difficulty, severe rash, jaundice, dark urine, severe abdominal pain, fainting, or unusually heavy bleeding. Persistent bleeding needs assessment rather than dose changes without advice.

Interactions

Medicines that induce liver enzymes, such as phenobarbital, phenytoin, carbamazepine, rifampin, rifabutin, and some herbal products, can increase dydrogesterone metabolism and reduce its effect. Tell the clinician about all prescription medicines, supplements, and herbal remedies, including St John’s wort.

Patients who buy Duphaston with a valid prescription should ask a pharmacist to check new medicines for compatibility. The Duphaston price is not a measure of authenticity, suitability, or safety. Medical review is particularly important if symptoms persist, bleeding changes, or pregnancy occurs during treatment.

Medical disclaimer: This content is informational and does not replace advice, diagnosis, or treatment from a licensed healthcare professional. Duphaston is a prescription medicine, and patients should follow their prescriber’s directions and seek professional advice for questions about their treatment.